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Biomedical Plasmas - NCPST - Page 5

Biomedical Plasmas

Plasmas are exploited for applications in biomedicine, for example in sterilisation, tackling antimicrobial resistance and new cancer therapeutics.

https://ieeexplore.ieee.org/abstract/document/6894576: A.M. Hirst et al. IEEE Trans. Plasma Sci. 42(10) 2740 (2004) doi: 10.1109/TPS.2014.2351453.

About the Research Area

The main motivation of LTPS for biomedical applications stems from their ability to generate and deliver reactive atomic and molecular species (both long- and short-lived), along with other active components such as UV, charged particles, and electric fields, under ambient conditions to a target. LTPs can stimulate specific biological responses, this is not only, but at least significantly due to the fact that low temperature plasma generated Reactive Oxygen Nitrogen Species (RONS) are the same as the RONS produced endogenously in the human body. They mediate many physiological processes, such as cell-to-cell signalling, immune response, wound healing and cell death processes, so therefore the plasma produced species are expected to mimic the functions of their native counterparts. Many existing clinical therapies already rely on these. The advantage of LTPs is that they directly and simultaneously produce these components offering unique synergies capable of stimulating specific biological responses. Our research involves understanding the plasma driven mechanisms of action and engineering controllable plasma delivery strategies.

Biomedical Plasmas Publications

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Electron dynamics in a radio-frequency-driven microatmospheric pressure plasma jet. Schaper, L; Waskoenig, J; Kong, M.G; Schulz-Von Der Gathen, V; Gans, T. IEEE Transactions on Plasma Science 2011

Design of experiments study of hydroxyapatite synthesis for orthopaedic application using fractional factorial design. Kehoe, S; Ardhaoui, M; Stokes, J. Journal of Materials Engineering and Performance 2011

Box-Behnken design of experiments investigation of hydroxyapatite synthesis for orthopedic applications. Kehoe, S; Stokes, J. Journal of Materials Engineering and Performance 2011

Effect of vibration on the shear strength of impacted bone graft in revision hip surgery. Brennan, S.A; Brabazon, D; O’Byrne, J.M. Journal of Bone and Joint Surgery – Series B 2011

Thermal sprayed hydroxyapatite-silver coatings with antimicrobial properties. Podporska, J; Quilty, B; Devery, R; Stokes, J. 24th European Conference on Biomaterials – Annual Conference of the European Society for Biomaterials 2011

Association between essential trace and toxic elements in scalp hair samples of smokers rheumatoid arthritis subjects. Afridi, H.I; Kazi, T.G; Brabazon, D; Naher, S. Science of the Total Environment 2011

Evaluation of essential trace and toxic elements in scalp hair samples of smokers and alcohol user hypertensive patients. Afridi, H.I; Brabazon, D; Kazi, T.G; Naher, S. Biological Trace Element Research 2011

Comparative metal distribution in scalp hair of Pakistani and Irish referents and hypertensive patients. Afridi, H.I; Brabazon, D; Kazi, T.G; Naher, S; Nesterenko, E. Biological Trace Element Research 2011

Viscoelastic impact characterisation of solid sports balls used in the Irish sport of Hurling. Collins, F; Brabazon, D; Moran, K. Sports Engineering 2011

Design of experiment analysis of the Sulzer Metco DJ high velocity oxy-fuel coating of hydroxyapatite for orthopedic applications. Hasan, S; Stokes, J. Journal of Thermal Spray Technology 2011

Experimental-modeling study of an atmospheric-pressure helium discharge propagating in a thin dielectric tube. Jansky, J; Algwari, Q.T; O’Connell, D; Bourdon, A. IEEE Transactions on Plasma Science 2012

Cold atmospheric pressure plasma jets: Interaction with plasmid DNA and tailored electron heating using dual-frequency excitation. Niemi, K; O’Neill, C; Cox, L.J; Waskoenig, J; Hyland, W.B; McMahon, S.J; Reuter, S; Currell, F.J; Graham, W.G; O’Connell, D; Gans, T. AIP Conference Proceedings 2012

Eradication of Pseudomonas aeruginosa Biofilms by Atmospheric Pressure Non-Thermal Plasma. Alkawareek, M.Y; Algwari, Q.T; Laverty, G; Gorman, S.P; Graham, W.G; O’Connell, D; Gilmore, B.F. PLoS ONE 2012

Application of atmospheric pressure nonthermal plasma for the in vitro eradication of bacterial biofilms. Alkawareek, M.Y; Algwari, Q.T; Gorman, S.P; Graham, W.G; O’Connell, D; Gilmore, B.F. FEMS Immunology and Medical Microbiology 2012

Detection of atomic oxygen and nitrogen created in a radio-frequency-driven micro-scale atmospheric pressure plasma jet using mass spectrometry. Maletić, D; Puač, N; Lazović, S; Malović, G; Gans, T; Schulz-Von Der Gathen, V; Petrović, Z.L. Plasma Physics and Controlled Fusion 2012

Permeability of rapid prototyped artificial bone scaffold structures. Lipowiecki, M; Ryvolova, M; Tottosi, A; Naher, S; Brabazon, D. Advanced Materials Research 2012

Interaction between zinc, cadmium, and lead in scalp hair samples of pakistani and irish smokers rheumatoid arthritis subjects in relation to controls. Afridi, H.I; Kazi, T.G; Brabazon, D; Naher, S. Biological Trace Element Research 2012

Interaction between essential trace and toxic elements in the scalp hair samples of smokers and alcohol user diabetics. Afridi, H.I; Kazi, T.G; Brabazon, D; Naher, S. International Journal of Diabetes in Developing Countries 2012

Simulation of the impact response of a sliotar core with linear and non-linear contact models. Hanley, K; Collins, F; Cronin, K; Byrne, E; Moran, K; Brabazon, D. International Journal of Impact Engineering 2012

Low-energy plasma spray (LEPS) deposition of hydroxyapatite/poly-ε- caprolactone biocomposite coatings. Garcia-Alonso, D; Parco, M; Stokes, J; Looney, L. Journal of Thermal Spray Technology 2012

Microbial monitoring of the hospital environment: why and how?. Galvin, S; Dolan, A; Cahill, O; Daniels, S; Humphreys, H. Journal of Hospital Infection 2012

A powered technique for inserting acetabular cups. Naher, S; O’Callaghan, D; Brabazon, D. Advanced Materials Research 2012

The antimicrobial effects of helium and helium-air plasma on Staphylococcus aureus and Clostridium difficile. Galvin, S; Cahill, O; O’Connor, N; Cafolla, A.A; Daniels, S; Humphreys, H. Letters in Applied Microbiology 2013