Biomedical Plasmas

Plasmas are exploited for applications in biomedicine, for example in sterilisation, tackling antimicrobial resistance and new cancer therapeutics. A.M. Hirst et al. IEEE Trans. Plasma Sci. 42(10) 2740 (2004) doi: 10.1109/TPS.2014.2351453.

About the Research Area

The main motivation of LTPS for biomedical applications stems from their ability to generate and deliver reactive atomic and molecular species (both long- and short-lived), along with other active components such as UV, charged particles, and electric fields, under ambient conditions to a target. LTPs can stimulate specific biological responses, this is not only, but at least significantly due to the fact that low temperature plasma generated Reactive Oxygen Nitrogen Species (RONS) are the same as the RONS produced endogenously in the human body. They mediate many physiological processes, such as cell-to-cell signalling, immune response, wound healing and cell death processes, so therefore the plasma produced species are expected to mimic the functions of their native counterparts. Many existing clinical therapies already rely on these. The advantage of LTPs is that they directly and simultaneously produce these components offering unique synergies capable of stimulating specific biological responses. Our research involves understanding the plasma driven mechanisms of action and engineering controllable plasma delivery strategies.

Biomedical Plasmas Publications


Optimisation of anaerobic digestion of pot ale after thermochemical pre-treatment through Response Surface Methodology. Gunes, B; Stokes, J; Davis, P; Connolly, C; Lawler, J. Biomass and Bioenergy 2021

MXene materials based printed flexible devices for healthcare, biomedical and energy storage applications. Sreenilayam, S.P; Ul Ahad, I; Nicolosi, V; Brabazon, D. Materials Today 2021

Fed-Batch System for Propagation of Brewer’s Yeast. Donnelly, D; Blanchard, L; Dabros, M; O’Hara, S; Brabazon, D; Foley, G; Freeland, B. Journal of the American Society of Brewing Chemists 2021

The potential use of a cold atmospheric plasma jet for decontamination of hospital surfaces. A pilot study. Fallon, M; Kennedy, S; Kumar, S; Daniels, S; Humphreys, H. Plasma Medicine 2021

Chemical kinetics and density measurements of OH in an atmospheric pressure He + O2+ H2O radiofrequency plasma. Brisset, A; Gibson, A.R; Schröter, S; Niemi, K; Booth, J.-P; Gans, T; O’Connell, D; Wagenaars, E. Journal of Physics D: Applied Physics 2021

Challenges in assessing contamination levels and novel decontamination technologies in the critical care setting. Kearney, A.D; Boyle, M.A; Babu, S.K; Fallon, M; Segurado, R; Codd, M; O’Rourke, J; Stevens, N.T; Carling, P.C; Daniels, S; Humphreys, H. Infection Control and Hospital Epidemiology 2020

Replica molding of cicada wings: The role of water at point of synthesis on nanostructure feature size. Flynn, S.P; Daniels, S; Rodriguez, B.J; Kelleher, S.M. Biointerphases 2020

Trace multi-class organic explosives analysis in complex matrices enabled using LEGO®-inspired clickable 3D-printed solid phase extraction block arrays. Irlam, R.C; Hughes, C; Parkin, M.C; Beardah, M.S; O’Donnell, M; Brabazon, D; Barron, L.P. Journal of Chromatography A 2020

Emerging technology trends in point-of-care diagnostics. Hughes, C; Sreenilayam, S.P; Afkham, Y; Brabazon, D. Proceedings – 2020 International Conference on Assistive and Rehabilitation Technologies, iCareTech 2020 2020

Investigation of a large gap cold plasma reactor for continuous in-package decontamination of fresh strawberries and spinach. Ziuzina, D; Misra, N.N; Han, L; Cullen, P.J; Moiseev, T; Mosnier, J.P; Keener, K; Gaston, E; Vilaró, I; Bourke, P. Innovative Food Science and Emerging Technologies 2020

Helium metastable species generation in atmospheric pressure RF plasma jets driven by tailored voltage waveforms in mixtures of He and N2. Korolov, I; Leimkühler, M; Böke, M; Donkó, Z; Schulz-Von Der Gathen, V; Bischoff, L; Hübner, G; Hartmann, P; Gans, T; Liu, Y; Mussenbrock, T; Schulze, J. Journal of Physics D: Applied Physics 2020

Effect of non-thermal plasma technology on microbial inactivation and total phenolic content of a model liquid food system and black pepper grains. Charoux, C.M.G; Free, L; Hinds, L.M; Vijayaraghavan, R.K; Daniels, S; O’Donnell, C.P; Tiwari, B.K. LWT 2020

The formation of atomic oxygen and hydrogen in atmospheric pressure plasmas containing humidity: Picosecond two-photon absorption laser induced fluorescence and numerical simulations. Schröter, S; Bredin, J; Gibson, A.R; West, A; Dedrick, J.P; Wagenaars, E; Niemi, K; Gans, T; O’Connell, D. Plasma Sources Science and Technology 2020

Reproducibility of ‘COST reference microplasma jets’. Riedel, F; Golda, J; Held, J; Davies, H.L; Van Der Woude, M.W; Bredin, J; Niemi, K; Gans, T; Schulz-Von Der Gathen, V; O’Connell, D. Plasma Sources Science and Technology 2020

Notch signalling is a potential resistance mechanism of progenitor cells within patient-derived prostate cultures following ROS-inducing treatments. Packer, J.R; Hirst, A.M; Droop, A.P; Adamson, R; Simms, M.S; Mann, V.M; Frame, F.M; O’Connell, D; Maitland, N.J. FEBS Letters 2020

Cold atmospheric plasma, the removal of blood from steel and its effect on staphylococcal biofilm formation. A pilot study. Fallon, M; Boyle, M; Kennedy, S; Daniels, S; Humphreys, H. Clinical Plasma Medicine 2020

Biophysical characterisation of DNA origami nanostructures reveals inaccessibility to intercalation binding sites. Miller, H.L; Contera, S; Wollman, A.J.M; Hirst, A; Dunn, K.E; Schröter, S; O’Connell, D; Leake, M.C. Nanotechnology 2020

Wearable devices for monitoring work related musculoskeletal and gait disorders. Sreenilayam, S.P; Afkham, Y; Hughes, C; Ahad, I.U; Hopper, L; Boran, A; Brabazon, D. Proceedings – 2020 International Conference on Assistive and Rehabilitation Technologies, iCareTech 2020 2020

Laryngoscope burn risk in neonatal intubation. Ryan, E; O Neill, P; Brabazon, D; Murphy, J.F.A. European Journal of Pediatrics 2019

Standardized traction versus side-bending radiographs in adolescent idiopathic scoliosis: A preliminary study. O’Neill, C.J; Brennan, S.A; Quinn, C; Brabazon, D; Kiely, P.J. Journal of Pediatric Orthopaedics Part B 2019

Review of recent research trends in assistive technologies for rehabilitation. Aqel, M.O.A; Brabazon, D; Issa, A; Elsharif, A.A; Ghaben, S; Alajerami, Y.S.M; Khalaf, H; Alrayyes, T; Bratanov, D; Debeljak, M. Proceedings – 2019 International Conference on Promising Electronic Technologies, ICPET 2019 2019

Improving precision in the prediction of laser texturing and surface interference of 316L assessed by neural network and adaptive neuro-fuzzy inference models. Sohrabpoor, H; Mousavian, R.T; Obeidi, M; Ahad, I.U; Brabazon, D. International Journal of Advanced Manufacturing Technology 2019

Corrigendum: Concepts and characteristics of the ‘COST Reference Microplasma Jet’ (Journal of Physics D: Applied Physics (2016) 49 (084003) DOI: 10.1088/0022-3727/49/8/084003). Golda, J; Held, J; Redeker, B; Konkowski, M; Beijer, P; Sobota, A; Kroesen, G; Braithwaite, N.S.J; Reuter, S; Turner, M.M; Gans, T; O’Connell, D; Schulz-Von Der Gathen, V. Journal of Physics D: Applied Physics 2019

Chemical kinetics in an atmospheric pressure helium plasma containing humidity. Schröter, S; Wijaikhum, A; Gibson, A.R; West, A; Davies, H.L; Minesi, N; Dedrick, J; Wagenaars, E; De Oliveira, N; Nahon, L; Kushner, M.J; Booth, J.-P; Niemi, K; Gans, T; O’Connell, D. Physical Chemistry Chemical Physics 2018

Nontarget Biomolecules Alter Macromolecular Changes Induced by Bactericidal Low-Temperature Plasma. Privat-Maldonado, A; Gorbanev, Y; O’Connell, D; Vann, R; Chechik, V; Van Der Woude, M.W. IEEE Transactions on Radiation and Plasma Medical Sciences 2018

Decontamination of hospital surfaces with multijet cold plasma: A method to enhance infection prevention and control?. Cahill, O.J; Claro, T; Cafolla, A.A; Stevens, N.T; Daniels, S; Humphreys, H. Infection Control and Hospital Epidemiology 2017

Cold Plasma Technology and Reducing Surface Bacterial Counts: A Pilot Study. Claro, T; Fay, R; Murphy, C; O’Connor, N; Daniels, S; Humphreys, H. Infection Control and Hospital Epidemiology 2017

Controlled production of atomic oxygen and nitrogen in a pulsed radio-frequency atmospheric-pressure plasma. Dedrick, J; Schröter, S; Niemi, K; Wijaikhum, A; Wagenaars, E; De Oliveira, N; Nahon, L; Booth, J.P; O’Connell, D; Gans, T. Journal of Physics D: Applied Physics 2017