Biomedical Plasmas

Plasmas are exploited for applications in biomedicine, for example in sterilisation, tackling antimicrobial resistance and new cancer therapeutics.

https://ieeexplore.ieee.org/abstract/document/6894576: A.M. Hirst et al. IEEE Trans. Plasma Sci. 42(10) 2740 (2004) doi: 10.1109/TPS.2014.2351453.

About the Research Area

The main motivation of LTPS for biomedical applications stems from their ability to generate and deliver reactive atomic and molecular species (both long- and short-lived), along with other active components such as UV, charged particles, and electric fields, under ambient conditions to a target. LTPs can stimulate specific biological responses, this is not only, but at least significantly due to the fact that low temperature plasma generated Reactive Oxygen Nitrogen Species (RONS) are the same as the RONS produced endogenously in the human body. They mediate many physiological processes, such as cell-to-cell signalling, immune response, wound healing and cell death processes, so therefore the plasma produced species are expected to mimic the functions of their native counterparts. Many existing clinical therapies already rely on these. The advantage of LTPs is that they directly and simultaneously produce these components offering unique synergies capable of stimulating specific biological responses. Our research involves understanding the plasma driven mechanisms of action and engineering controllable plasma delivery strategies.

DCU Cancer Research

Biomedical Plasmas Publications

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Low-temperature Plasmas, Biomedical Applications

Gas and heat dynamics of a micro-scaled atmospheric pressure plasma reference jet. Kelly, S; Golda, J; Turner, M.M; Schulz-Von Der Gathen, V. Journal of Physics D: Applied Physics 2015

Low-temperature Plasmas, Biomedical Applications

Cold-air atmospheric pressure plasma against clostridium difficile spores: A potential alternative for the decontamination of hospital inanimate surfaces. Claro, T; Cahill, O.J; O’Connor, N; Daniels, S; Humphreys, H. Infection Control and Hospital Epidemiology 2015

Materials Growth and Processing, Biomedical Applications

Biocompatibility and bioimaging application of carbon nanoparticles synthesized by phosphorus pentoxide combustion method. Roy, S; Korzeniowska, B; Dixit, C.K; Manickam, G; Daniels, S; McDonagh, C. Journal of Nanomaterials 2015

Biomedical Applications, Materials Growth and Processing

Synthesis and characterisation of far-red fluorescent cyanine dye doped silica nanoparticles using a modified microemulsion method for application in bioassays. Nooney, R; O’Connell, C; Roy, S; Boland, K; Keegan, G; Kelleher, S; Daniels, S; McDonagh, C. Sensors and Actuators, B: Chemical 2015

Biomedical Applications, Microfluidics

Solvent-selective routing for centrifugally automated solid-phase purification of RNA. Dimov, N; Clancy, E; Gaughran, J; Boyle, D; Mc Auley, D; Glynn, M.T; Dwyer, R.M; Coughlan, H; Barry, T; Barrett, L.M; Smith, T.J; Ducrée, J. Microfluidics and Nanofluidics 2015

Biomedical Applications

Detecting Clostridium difficile spores from inanimate surfaces of the hospital environment: Which method is best?. Claro, T; Daniels, S; Humphreys, H. Journal of Clinical Microbiology 2014

Biomedical Applications

What is the best method? Recovery of methicillin-resistant Staphylococcus aureus and extended-spectrum β-lactamase-producing Escherichia coli from inanimate hospital surfaces. Claro, T; Galvin, S; Cahill, O; Fitzgerald-Hughes, D; Daniels, S; Humphreys, H. Infection Control and Hospital Epidemiology 2014

Biomedical Applications

Relationship between toxic metals exposure via cigarette smoking and rheumatoid arthritis. Afridi, H.I; Kazi, T.G; Talpur, F.N; Naher, S; Brabazon, D. Clinical Laboratory 2014

Biomedical Applications

Influence of substrate metal alloy type on the properties of hydroxyapatite coatings deposited using a novel ambient temperature deposition technique. Barry, J.N; Cowley, A; McNally, P.J; Dowling, D.P. Journal of Biomedical Materials Research – Part A 2014

Biomedical Applications

Advances in three-dimensional rapid prototyping of microfluidic devices for biological applications. O’Neill, P.F; Ben Azouz, A; Vázquez, M; Liu, J; Marczak, S; Slouka, Z; Chang, H.C; Diamond, D; Brabazon, D. Biomicrofluidics 2014

Low-temperature Plasmas, Biomedical Applications, Environmental Applications

Influence of high voltage atmospheric cold plasma process parameters and role of relative humidity on inactivation of Bacillus atrophaeus spores inside a sealed package. Patil, S; Moiseev, T; Misra, N.N; Cullen, P.J; Mosnier, J.P; Keener, K.M; Bourke, P. Journal of Hospital Infection 2014

Low-temperature Plasmas, Biomedical Applications

Post-discharge gas composition of a large-gap DBD in humid air by UV-Vis absorption spectroscopy. Moiseev, T; Misra, N.N; Patil, S; Cullen, P.J; Bourke, P; Keener, K.M; Mosnier, J.P. Plasma Sources Science and Technology 2014

Low-temperature Plasmas, Biomedical Applications

Afterglow chemistry of atmospheric-pressure helium-oxygen plasmas with humid air impurity. Murakami, T; Niemi, K; Gans, T; O’Connell, D; Graham, W.G. Plasma Sources Science and Technology 2014

Biomedical Applications, Low-temperature Plasmas

Cold atmospheric pressure plasma and decontamination. Can it contribute to preventing hospital-acquired infections?. O’Connor, N; Cahill, O; Daniels, S; Galvin, S; Humphreys, H. Journal of Hospital Infection 2014

Low-temperature Plasmas, Biomedical Applications

Interactions of a non-thermal atmospheric pressure plasma effluent with PC-3 prostate cancer cells. Gibson, A.R; McCarthy, H.O; Ali, A.A; O’Connell, D; Graham, W.G. Plasma Processes and Polymers 2014

Low-temperature Plasmas, Biomedical Applications

Cold air plasma to decontaminate inanimate surfaces of the hospital environment. Cahill, O.J; Claro, T; O’Connor, N; Cafolla, A.A; Stevens, N.T; Daniels, S; Humphreys, H. Applied and Environmental Microbiology 2014

Low-temperature Plasmas, Biomedical Applications

Low temperature plasma causes double-strand break DNA damage in primary epithelial cells cultured from a human prostate Tumor. Hirst, A.M; Frame, F.M; Maitland, N.J; O’Connell, D. IEEE Transactions on Plasma Science 2014

Low-temperature Plasmas, Biomedical Applications

A spatially resolved retarding field energy analyzer design suitable for uniformity analysis across the surface of a semiconductor wafer. Sharma, S; Gahan, D; Kechkar, S; Daniels, S; Hopkins, M.B. Review of Scientific Instruments 2014

Biomedical Applications

Comparative metal distribution in scalp hair of Pakistani and Irish referents and diabetes mellitus patients. Afridi, H.I; Kazi, T.G; Brabazon, D; Naher, S; Talpur, F.N. Clinica Chimica Acta 2013

Biomedical Applications

Estimation of toxic elements in the samples of different cigarettes and their impact on human health of Irish hypertensive consumers. Afridi, H.I; Kazi, T.G; Talpur, F.N; Brabazon, D; Naher, S. Clinica Chimica Acta 2013

Biomedical Applications

Protein integrated, functionally active silver nanoplanar structures for enhanced SPR. Roy, S; Dixit, C.K; Gandhiraman, R; Prendergast, U; Daniels, S; O’Kennedy, R; McDonagh, C. Journal of Physical Chemistry C 2013

Biomedical Applications, Laser Plasmas and Spectroscopy

Fragmentation of neutral amino acids and small peptides by intense, femtosecond laser pulses. Duffy, M.J; Kelly, O; Calvert, C.R; King, R.B; Belshaw, L; Kelly, T.J; Costello, J.T; Timson, D.J; Bryan, W.A; Kierspel, T; Turcu, I.C.E; Cacho, C.M; Springate, E; Williams, I.D; Greenwood, J.B. Journal of the American Society for Mass Spectrometry 2013

Biomedical Applications

Identification of sleep apnea events using discrete wavelet transform of respiration, ECG and accelerometer signals. Sweeney, K.T; Mitchell, E; Gaughran, J; Kane, T; Costello, R; Coyle, S; O’Connor, N.E; Diamond, D. 2013 IEEE International Conference on Body Sensor Networks, BSN 2013 2013

Biomedical Applications

Electrospun composites of PHBV, silk fibroin and nano-hydroxyapatite for bone tissue engineering. Paşcu, E.I; Stokes, J; McGuinness, G.B. Materials Science and Engineering C 2013